Researchers in Sheffield have published a revolutionary paper revealing the molecular structure of bacterial cell walls for the first time using atomic force microscopy.
In the paper, published in Nature, scientists from the Physics and Astronomy department and the department of Molecular Biology and Biotechnology at the University of Sheffield shared the first high-resolution images of the structure of the cell wall of bacteria. These images will provide valuable insights for scientists working to develop new antibiotics to tackle antibiotic resistance.
When extra experiments were requested as part of the article’s review process extra microfabricated silicon grids were required to immobilise the Staphylococcus aureus bacteria used in the study, NuNano was able to draw on our extensive fabrication experience and capabilities to quickly deliver the custom silicon substrate.
One of the authors of the paper, Laia Pasquina-Lemonche, said, ‘We were pressed for time and NuNano quickly provided us with the custom-made silicon grids which allowed us to do the final experiments required by the reviewers. Looking forward to more projects!’
You can read more about the paper and it’s impact on the University of Sheffield website and read the paper online.
An AFM image of a living bacterial cell from the study, sitting in the NuNano produced silicon grid. Image courtesy of Laia Pasquina-Lemonche.
NuNano specialises in manufacturing bespoke cantilever sensors but has the capability to microfabricate a wide range of substrates and devises. You can read a case study about custom AFM probes that NuNano produced for James Bowen of the Open University and find out more about our capabilities and how to get in touch with us about your next project here: https://www.nunano.com/bespoke-afm-probes